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Structure and Biological Activity of Heparinoid

[ Vol. 5 , Issue. 5 ]

Author(s):

Neeraj Kumar, A. Bentolila and A. J. Domb   Pages 441 - 447 ( 7 )

Abstract:


Heparin is a biogenic anionic charged sulfated polysaccharide that has a range of desired activities including inhibition of tumor metastasis and inhibition of restenosis. However, its clinical use is limited to treating blood-clotting disorders. Anionic macromolecules called heparinoids have been investigated with the objective of developing heparin-like molecules with reduced anti-coagulant activity and selective antimetastasis and anti-restenosis activity. This mini-review summarizes the synthesis and biological activity of the main synthetic heparinoids reported in the past three decades.

Keywords:

heparinoid, heparin, polyanion, heparanase inhibitors, poly(acryl amino acid), fgf release, heparan sulfate, anticoagulant

Affiliation:

Department of Medicinal Chemistry and Natural Products, School of Pharmacy- Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91220, IL.



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