Neeraj Kumar, A. Bentolila and A. J. Domb Pages 441 - 447 ( 7 )
Heparin is a biogenic anionic charged sulfated polysaccharide that has a range of desired activities including inhibition of tumor metastasis and inhibition of restenosis. However, its clinical use is limited to treating blood-clotting disorders. Anionic macromolecules called heparinoids have been investigated with the objective of developing heparin-like molecules with reduced anti-coagulant activity and selective antimetastasis and anti-restenosis activity. This mini-review summarizes the synthesis and biological activity of the main synthetic heparinoids reported in the past three decades.
heparinoid, heparin, polyanion, heparanase inhibitors, poly(acryl amino acid), fgf release, heparan sulfate, anticoagulant
Department of Medicinal Chemistry and Natural Products, School of Pharmacy- Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91220, IL.