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Synthesis and Pharmacology of New Camptothecin Drugs

[ Vol. 5 , Issue. 5 ]

Author(s):

Russell W. Driver and Li-Xi Yang   Pages 425 - 439 ( 15 )

Abstract:


Camptothecin (CPT) drugs exhibit antineoplastic activity against colorectal, breast, lung and ovarian cancers. This review briefly summarizes the pharmacology of CPT drugs, examines four strategies and methods for the synthesis of camptothecins, and finally discusses homocamptothecins and silatecans, two new classes of CPT analog.

Keywords:

camptothecin, homocamptothecin, silatecan, pharmacology, synthesis

Affiliation:

Radiobiology Laboratory, California Pacific Medical Center Research Institute, ɚ, OPR Bldg.,3801 Sacramento Street, San Francisco, CA 94118, USA.



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