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Knowledge-Driven Lead Discovery

[ Vol. 5 , Issue. 11 ]

Author(s):

Bernard Pirard   Pages 1045 - 1052 ( 8 )

Abstract:


Virtual screening encompasses several computational approaches which have proven valuable for identifying novel leads. These approaches rely on available information. Herein, we review recent successful applications of virtual screening. The extension of virtual screening methodologies to target families is also briefly discussed.

Keywords:

virtual screening, chemical biology, chemogenomics, lead discovery, similarity searching, pharmacophore, data mining, docking

Affiliation:

Aventis Pharma Deutschland GmbH, A Company of the Sanofi-Aventis Group, Chemical Sciences, Drug Design, Building G878, D-65926 Frankfurt am Main, Germany.



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