A. Masuyama, J.- M. Wu, M. Nojima, H.- S. Kim and Y. Wataya Pages 1035 - 1043 ( 9 )
In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.
1,2,4,5-tetraoxacycloalkanes, 1,2,5,6-tetraoxacycloalkanes, 1,2,6,7-tetraoxaspiro[7.11]nonadecane, antimalarial activity, medium-sized cyclic peroxides, cyclization methods, p. falciparum, p. berghei
Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan.