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Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review

[ Vol. 5 , Issue. 11 ]

Author(s):

Thomas Scior, Antonio Guevara-Garcia, Philippe Bernard, Quoc-Tuan Do, David Domeyer and Stefan Laufer   Pages 995 - 1008 ( 14 )

Abstract:


Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.

Keywords:

vanadium, anti-diabetic, insulin-mimetic, phospho-mimetic, ptp-1b, toxicity, molecular design

Affiliation:

The Facultad de Ciencias Quimicas, Benemerita Universidad Autonoma de Puebla, Ciudad Universitaria C.U. Edificio 139, 14 Sur con Avenida San Claudio, C.P. 72570 Colonia San Manuel, Mexico.



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