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Second-Generation KATP Channel Openers

[ Vol. 5 , Issue. 11 ]

Author(s):

Raimund Mannhold and Gerard Leclerc   Pages 961 - 969 ( 9 )

Abstract:


This review discusses structural aspects of second-generation KATP channel openers (KCOs), which exhibit improved tissue-selectivity. Their therapeutic profile is debated with main focus on cardiac ischemia, asthma, and urinary incontinence.

Keywords:

katp channel openers (kcos), benzopyrans, cyclobutenediones, dihydropyridine related structures, tertiary carbinols, structure-activity relationships, therapeutic potential, myocardial ischemia, asthma, urinary incontinence

Affiliation:

Department of Laser Medicine, Molecular Drug Research Group, Heinrich-Heine-Universitat, Universitatsstra├če 1, 40225 Dusseldorf, Germany.



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