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The Brown Adipose Cell: A Unique Model for Understanding the Molecular Mechanism of Insulin Resistance

[ Vol. 5 , Issue. 3 ]

Author(s):

Angela M. Valverde and Manuel Benito   Pages 269 - 278 ( 10 )

Abstract:


Type 2 diabetes mellitus (NIDDM) is a complex metabolic disease that occurs when insulin secretion can no longer compensate insulin resistance in peripheral tissues. At the molecular level, insulin resistance correlates with impaired insulin signaling. This review provides new insights into the molecular mechanisms of insulin action and resistance in brown adipose tissue (BAT) and pinpoints the role of BAT in the control of glucose homeostasis.

Keywords:

brown adipocytes, insulin signaling, insulin resistance, insulin receptor, insulin receptor substrates, adipocyte differentiation

Affiliation:

Instituto de Bioquimica / Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Ciudad Universitaria, 28040 Madrid, Spain.



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