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Current Status and Future Possibilities of Nitric Oxide-Donor Drugs: Focus on S-Nitrosothiols

[ Vol. 5 , Issue. 3 ]

Author(s):

H. H. Al-Sa'doni and A. Ferro   Pages 247 - 254 ( 8 )

Abstract:


Drugs which release nitric oxide (NO) have great therapeutic potential. The organic nitrates and sodium nitroprusside have been used in cardiovascular therapeutics for many years, but several drawbacks limit their usefulness. In this review, we consider novel and potential future developments in NO-donor drugs, and the possible clinical usefulness of such compounds.

Keywords:

nitric oxide, nitric oxide donors, s-nitrosothiols, therapeutics

Affiliation:

Department of Clinical Pharmacology, Kingapos;s College London, St Thomas' Hospital, LambethPalace Road, London SE1 7EH, UK.



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