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Photoaffinity Labeling of P-Glycoprotein

[ Vol. 5 , Issue. 2 ]


Michael Peer, Edina Csaszar, Elisabeth Vorlaufer, Stephan Kopp and Peter Chiba   Pages 165 - 172 ( 8 )


The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and propafenones. These studies allowed identification of protein regions, which are involved in ligand interaction.


multidrug resistance, p-glycoprotein, affinity labeling


Department of Medical Chemistry, Medical University of Vienna, Waehringerstrasse 10, 1090Vienna, Austria.

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