Michael Peer, Edina Csaszar, Elisabeth Vorlaufer, Stephan Kopp and Peter Chiba Pages 165 - 172 ( 8 )
The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and propafenones. These studies allowed identification of protein regions, which are involved in ligand interaction.
multidrug resistance, p-glycoprotein, affinity labeling
Department of Medical Chemistry, Medical University of Vienna, Waehringerstrasse 10, 1090Vienna, Austria.