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Corticotropin-Releasing Factor Binding Protein - A Ligand Trap?

[ Vol. 5 , Issue. 10 ]

Author(s):

Olaf Jahn, Jelena Radulovic, Oliver Stiedl, Hossein Tezval, Klaus Eckart and Joachim Spiess   Pages 953 - 960 ( 8 )

Abstract:


The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.

Keywords:

corticotropin-releasing factor (crf), crf binding protein (crfbp), crfbp inhibitor, urocortin, cognitive deficits

Affiliation:

Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine,Hermann-Rein-Str. 3, 37075 Goettingen, Germany.



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