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Advances in Prodrug Design

[ Vol. 5 , Issue. 10 ]

Author(s):

Antonio Tavora de Albuquerque Silva, Man C. Chung, Lucia F. Castro, Rafael V. Carvalho Guido and Elizabeth I. Ferreira   Pages 893 - 914 ( 22 )

Abstract:


The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene- Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given.

Keywords:

prodrug design, latent advanced systems, macromolecules carriers, selective delivery systems

Affiliation:

Lapen - Laboratorio de Planejamento e Sintese de Quimioterapicos Potencialmente Ativos emEndemias Tropicais, Departamento de Farmacia, Faculdade de Ciencias Farmaceuticas, USP/SP, Brazil.



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