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Peroxisome Proliferator-Activated Receptor Agonists as Potential Therapeutic Agents in Multiple Sclerosis

[ Vol. 7 , Issue. 11 ]

Author(s):

Masaaki Niino   Pages 1129 - 1135 ( 7 )

Abstract:


Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for gene regulation in glucose and lipid metabolism. It has been recently implicated that PPARs regulate cellular proliferation and inflammatory responses; some agonists for PPARs ameliorate experimental autoimmune encephalomyelitis, a model of multiple sclerosis (MS) in humans. This article will outline current experimental evidence suggesting potential clinical benefits for patients with MS.

Keywords:

PPAR, multiple sclerosis, experimental autoimmune encephalomyelitis, cytokine, inflammation

Affiliation:

Department of Neurology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku,Sapporo, 060-8638, Japan.



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