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Peroxisome Proliferator-Activated Receptor Agonists as Potential Therapeutic Agents in Multiple Sclerosis

[ Vol. 7 , Issue. 11 ]


Masaaki Niino   Pages 1129 - 1135 ( 7 )


Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for gene regulation in glucose and lipid metabolism. It has been recently implicated that PPARs regulate cellular proliferation and inflammatory responses; some agonists for PPARs ameliorate experimental autoimmune encephalomyelitis, a model of multiple sclerosis (MS) in humans. This article will outline current experimental evidence suggesting potential clinical benefits for patients with MS.


PPAR, multiple sclerosis, experimental autoimmune encephalomyelitis, cytokine, inflammation


Department of Neurology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku,Sapporo, 060-8638, Japan.

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