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Heme Oxygenase-1: A Fundamental Guardian Against Oxidative Tissue Injuries in Acute Inflammation

[ Vol. 7 , Issue. 7 ]

Author(s):

T. Takahashi, H. Shimizu, H. Morimatsu, K. Inoue, R. Akagi, K. Morita, S. Sassa, T. Takahashi, H. Shimizu, H. Morimatsu, K. Inoue, R. Akagi, K. Morita and S. Sassa   Pages 745 - 753 ( 9 )

Abstract:


Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (HO- 1), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.

Keywords:

Carbon monoxide, heme, heme oxygenase-1, inflammation, liver injury, oxidative stress, renal injury, sepsis

Affiliation:

Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558, Japan., Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-choOkayama, 700-8558, Japan.



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