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Article Details


Tumor Suppression by DNA Base Excision Repair

[ Vol. 7 , Issue. 7 ]

Author(s):

G. Frosina and G. Frosina   Pages 727 - 743 ( 17 )

Abstract:


Base excision repair (BER) is the main pathway for repair of endogenous DNA damage. It was expected that different tumor types could derive from BER defects but to date this link is elusive. In vitro and molecular epidemiology studies may be used to unravel this issue.

Keywords:

DNA base excision repair, molecular epidemiology, oxidative DNA damage, 8-oxoguanine, glycosylase, mutation, in vitro neoplastic transformation, chemotherapy

Affiliation:

Department of Translational Oncology, Experimental Oncology “B” laboratory, Istituto Nazionale Ricerca Cancro, Largo Rosanna Benzi n. 10, 16132 Genova, Italy., Department of Translational Oncology, Experimental Oncology“B”laboratory, Istituto Nazionale Ricerca Cancro, Largo Rosanna Benzi n. 10, 16132 Genova, Italy.



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