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Development and Medical Application of Unsaturated Carbaglycosylamine Glycosidase Inhibitors

[ Vol. 7 , Issue. 7 ]

Author(s):

Seiichiro Ogawa, Miki Kanto, Yoshiyuki Suzuki, Seiichiro Ogawa, Miki Kanto and Yoshiyuki Suzuki   Pages 679 - 691 ( 13 )

Abstract:


This article reviews synthesis and structures of carbaglycosylamines, a group of carbocyclic sugar analogues. Some unsaturated derivatives are known to be potent glycosidase inhibitors. Among them, N-octyl-4-epi-??-valienamine as a lysosomal ??-galactosidase inhibitor is currently undergoing a new molecular therapeutic trial (chemical chaperone therapy) for control of the human ??-galactosidase deficiency disorder, GM1-gangliosidosis.

Keywords:

Carbasugars, aminocyclitols, 5a-carbaglycosylamines, glycosidase inhibitors, chemical chaperone therapy, lysosomal disease, GM1-gangliosidosis

Affiliation:

Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama, 223-8522 Japan., Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Hiyoshi,Kohoku-ku, Yokohama, 223-8522 Japan.



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