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A Search for Inhibitors of S100B, a Member of the S100 Family of Calcium-Binding Proteins

[ Vol. 7 , Issue. 6 ]

Author(s):

Joseph Markowitz, Alexander D. MacKerell and David J. Weber   Pages 609 - 616 ( 8 )

Abstract:


Typically, malignant melanoma has wild-type p53, and yet this cancer proliferates. S100B, which binds p53 and is up-regulated in melanoma, down-regulates wild-type p53 tumor suppressor function. Inhibitors of the S100B-p53 interaction were identified using computer aided drug design (CADD) combined with NMR methodologies and represent potentially new chemotherapeutics for melanoma.

Keywords:

S100B, p53, calcium, inhibitors, drug design, cancer

Affiliation:

Dept. of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N.Greene St., Baltimore, MD 21201, USA.



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