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Allosteric Enhancers for A1 Adenosine Receptor

[ Vol. 7 , Issue. 6 ]

Author(s):

Pier Giovanni Baraldi, Maria Antonietta Iaconinoto, Allan R. Moorman, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Olga Cruz Lopez, Francesca Fruttarolo, Mojgan Aghazadeh Tabrizi and Romeo Romagnoli   Pages 559 - 569 ( 11 )

Abstract:


Allosteric enhancers at the adenosine A1 receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, allosteric modulators at the adenosine A1 receptor have therapeutic potential as analgesics and neuroprotective agents. In particular, the compounds with improved potency as enhancers and reduced antagonist properties are mentioned.

Keywords:

A1-adenosine receptor, allosteric modulators, enhancer, cAMP content, neuroprotection

Affiliation:

Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17-19, 44100-Ferrara, Italy.



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