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Synthetic Approaches to the 2005 New Drugs

[ Vol. 7 , Issue. 4 ]


Subas M. Sakya, Jin Li and Kevin K.-C. Liu   Pages 429 - 450 ( 22 )


New drugs are introduced to the market every year and each individual drug represents a privileged structure for its biological target. In addition, these new chemical entities (NCEs) not only provide insights into molecular recognition, but also serve as drug-like leads for designing future new drugs. To these ends, this review covers the syntheses of 22 NCEs marketed in 2005.


Synthesis, new drug, new chemical entities, medicine, therapeutic agents


Pfizer Global Research and Development, Pfizer Inc., Groton, CT 06340, USA.

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