Quan Liu, Fang Xie, Raj Rolston, Paula I. Moreira, Akihiko Nunomura, Xiongwei Zhu, Mark A. Smith and George Perry Pages 171 - 180 ( 10 )
There is considerable evidence showing that oxidative damage is one of the earliest neuronal and pathological changes of Alzheimer disease and many, if not all, of the etiological and pathological causes of the disease are related, directly or indirectly, to free radical production and oxidative damage. Here we summarize the current body of knowledge suggestive that oxidative damage is, if not the key factor, certainly a major factor in Alzheimer disease. As such, therapeutic modalities encompassing antioxidants may be an effective approach to the treatment of neurodegenerative diseases and delay the aging process.
Antioxidant, calorie restriction, estrogen, free radical, glutathione, oxidation, oxidative stress, sirtuin, therapy, vitamin C
Department of Ophthalmology,University of California, San Diego, 9500 Gilman Drive 0946, La Jolla, California 92093-0946 USA.