Natural and Synthetic Cholera Toxin Antagonists

Author(s):

I. A. Velter, M. Politi, C. Podlipnik and F. Nicotra   Pages 159 - 170 ( 12 )

Abstract:

Cholera Toxin (CT) recognizes the cell membrane through specific interactions with ganglioside GM1. Recent structural elucidation of the CT/GM1 complex has allowed the rational design of artificial receptors for the toxin, which could function as anti-cholera drugs. The efforts towards the rational design of Cholera Toxin inhibitors will be presented.

Keywords:

Cholera toxin, ganglioside GM1, catechins, galactose, multivalency

Affiliation:

Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano-Bicocca, Piazza della Scienza 2, I-20126 Milano, Italy.

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