I. A. Velter, M. Politi, C. Podlipnik and F. Nicotra Pages 159 - 170 ( 12 )
Cholera Toxin (CT) recognizes the cell membrane through specific interactions with ganglioside GM1. Recent structural elucidation of the CT/GM1 complex has allowed the rational design of artificial receptors for the toxin, which could function as anti-cholera drugs. The efforts towards the rational design of Cholera Toxin inhibitors will be presented.
Cholera toxin, ganglioside GM1, catechins, galactose, multivalency
Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano-Bicocca, Piazza della Scienza 2, I-20126 Milano, Italy.