J. A. Gerrard, C. A. Hutton and M. A. Perugini Pages 151 - 157 ( 7 )
Association of proteins into homo- and hetero-oligomers plays an important role in a plethora of biological phenomena. Inhibition of these interactions is increasingly recognized as a valuable new direction in drug design. In this mini-review we consider inhibition of protein misfolding and aggregation, molecules that disrupt enzyme quaternary structure, and signaling inhibitors, as emerging drugs.
Protein-protein interactions, inhibitor, amyloid, HIV, drug design, small molecule-protein interaction
School of Biological Sciences,University of Canterbury, Christchurch, New Zealand.