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Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery

[ Vol. 7 , Issue. 2 ]


J. A. Gerrard, C. A. Hutton and M. A. Perugini   Pages 151 - 157 ( 7 )


Association of proteins into homo- and hetero-oligomers plays an important role in a plethora of biological phenomena. Inhibition of these interactions is increasingly recognized as a valuable new direction in drug design. In this mini-review we consider inhibition of protein misfolding and aggregation, molecules that disrupt enzyme quaternary structure, and signaling inhibitors, as emerging drugs.


Protein-protein interactions, inhibitor, amyloid, HIV, drug design, small molecule-protein interaction


School of Biological Sciences,University of Canterbury, Christchurch, New Zealand.

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