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myo-Inositol Monophosphatase: A Challenging Target for Mood Stabilising Drugs

[ Vol. 7 , Issue. 2 ]

Author(s):

D. J. Miller and R. K. Allemann   Pages 107 - 113 ( 7 )

Abstract:


myo-Inositol monophosphatase has long been a target for drug discovery. Recent work has given detailed insight into its mechanism and dynamics plus new activities and some novel series of inhibitors. The goal of a bio-available inhibitor for this enzyme, however, remains a major challenge for medicinal chemistry.

Keywords:

diacylglycerol, G-protein coupled receptor, Lithitum, myo-Inositol 1-phosphate, Circular dichroism, Zinc ion

Affiliation:

School of Chemistry, Main Building, Park Place, Cardiff University, Cardiff, CF10 3AT, UK.



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