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Hypothalamic Neuropeptide Systems as Targets for Potential Anti-Obesity Drugs

[ Vol. 7 , Issue. 1 ]

Author(s):

E. Dozio, M. Ruscica, M. Motta and P. Magni   Pages 11 - 19 ( 9 )

Abstract:


Food intake and energy homeostasis are controlled by peripheral humoral signals, afferent neuronal pathways to the brain and central signals, represented, in particular, by neuropeptides. This review reports the status of development of novel compounds targeting some hypothalamic neuropeptide systems which are currently viewed as potential targets to treat obesity.

Keywords:

NPY, AgRP, MCH, orexins, galanin, POMC, CART, CRH

Affiliation:

Istituto di Endocrinologia,Universita' degli Studi di Milano, via G. Balzaretti, 9, 20133 Milano–Italy.



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