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Carbohydrate Antigens: Synthesis Aspects and Immunological Applications in Cancer

[ Vol. 6 , Issue. 12 ]


Teresa Freire, Sylvie Bay, Sophie Vichier-Guerre, Richard Lo-Man and Claude Leclerc   Pages 1357 - 1373 ( 17 )


Tumor Associated Carbohydrate Antigens (TACAs) constitute powerful tools as tumor markers and as targets for anticancer immunotherapy. In this review, methods of production of glycopeptide-based vaccines, as well as results of preclinical and clinical studies in cancer patients are discussed.


Glycosylation, cancer, glycosyltransferase, synthesis, vaccine, immunotherapy, carbohydrate


Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, 25-28 rue Docteur Roux, 75015 Paris, France.

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