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Carbohydrate Antigens: Synthesis Aspects and Immunological Applications in Cancer

[ Vol. 6 , Issue. 12 ]

Author(s):

Teresa Freire, Sylvie Bay, Sophie Vichier-Guerre, Richard Lo-Man and Claude Leclerc   Pages 1357 - 1373 ( 17 )

Abstract:


Tumor Associated Carbohydrate Antigens (TACAs) constitute powerful tools as tumor markers and as targets for anticancer immunotherapy. In this review, methods of production of glycopeptide-based vaccines, as well as results of preclinical and clinical studies in cancer patients are discussed.

Keywords:

Glycosylation, cancer, glycosyltransferase, synthesis, vaccine, immunotherapy, carbohydrate

Affiliation:

Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, 25-28 rue Docteur Roux, 75015 Paris, France.



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