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New Insights into the Regulation of Liver Inflammation and Oxidative Stress

[ Vol. 6 , Issue. 12 ]

Author(s):

Natalia Ferre and Joan Claria   Pages 1321 - 1330 ( 10 )

Abstract:


Pro-inflammatory lipid mediators (i.e. eicosanoids), cytokines (i.e. TNF-α) and reactive oxygen species are targets of interest in the regulation of liver inflammation and oxidative stress. In the current review, we summarize recent advances in the pharmacological modulation of these pathways with especial emphasis on the participation of Kupffer cells, the liver resident macrophages and the cell type most directly related to the production of inflammatory mediators in this organ.

Keywords:

Cyclooxygenase, 5-lipoxygenase, TNF-α, TGF-β, reactive oxygen species

Affiliation:

Department of Biochemistry and Molecular Genetics, Hospital ClĂ­nic, Villarroel 170, Barcelona 08036,Spain.



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