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S-Layer Proteins as Key Components of a Versatile Molecular Construction Kit for Biomedical Nanotechnology

[ Vol. 6 , Issue. 8 ]

Author(s):

B. Schuster, D. Pum, M. Sara and U. B. Sleytr   Pages 909 - 920 ( 12 )

Abstract:


Surface (S)-layer proteins and S-layer fusion proteins incorporating functional sequences, self-assemble into monomolecular lattices on solid supports and on various lipid structures. Based on these S-layer proteins, supramolecular assemblies can be constructed which are envisaged for label-free detection systems, as affinity matrix, as anti-allergic immuno-therapeutics, as membrane protein-based screening devices, and as drug targeting and delivery systems.

Keywords:

Crystalline surface layer proteins, artificial virus, biomimetics, bottom-up strategy, S-layer fusion protein, microspheres-based detoxification system, nanobiotechnology

Affiliation:

Center for Nano-Biotechnology, University of Natural Resources and Applied Life Sciences Vienna, Gregor-Mendel-Strasse 33, 1180 Vienna, Austria.



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