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Leptin, Estrogens and Cancer

[ Vol. 6 , Issue. 8 ]

Author(s):

Maria del Carmen Maeso Fortuny, Buenaventura Brito Diaz and Antonio Cabrera de Leon   Pages 897 - 907 ( 11 )

Abstract:


Obesity is a state of leptin resistance in which the membrane leptin receptor and the JAK-STAT pathway are blocked. This leads to increased intracellular concentrations of lipid metabolites, increased non-oxidative metabolism by adipocytes, and stimulation of the cell estrogen cycle. These factors are potentially oncogenic via the shared mitogen-activated protein kinase (MAPK), mitogen/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK) cellular pathways.

Keywords:

Cancer, leptin, estrogen receptors

Affiliation:

Unidad de investigacion, Hospital de La Candelaria, Santa Cruz de Tenerife, Spain.



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