Maria del Carmen Maeso Fortuny, Buenaventura Brito Diaz and Antonio Cabrera de Leon Pages 897 - 907 ( 11 )
Obesity is a state of leptin resistance in which the membrane leptin receptor and the JAK-STAT pathway are blocked. This leads to increased intracellular concentrations of lipid metabolites, increased non-oxidative metabolism by adipocytes, and stimulation of the cell estrogen cycle. These factors are potentially oncogenic via the shared mitogen-activated protein kinase (MAPK), mitogen/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK) cellular pathways.
Cancer, leptin, estrogen receptors
Unidad de investigacion, Hospital de La Candelaria, Santa Cruz de Tenerife, Spain.