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Potential for Discovery of Neuroprotective Factors in Serum and Tissue from Hibernating Species

[ Vol. 6 , Issue. 8 ]

Author(s):

Austin P.Ross and Kelly L.Drew   Pages 875 - 884 ( 10 )

Abstract:


Hibernation is a unique phenotype displayed by a phylogenetically diverse group of organisms including several species of mammals and one species of primate. Here we review evidence for blood and tissue borne signaling molecules in hibernating animals, achievements in isolating and characterizing these molecules, and potential medicinal applications.

Keywords:

Heterothermic, Cytoprotective, Tolerance, Hibernation induction trigger, Endogenous factors, Metabolic suppression, Suspended animation, Plasma factors

Affiliation:

Institute of Arctic Biology, P.O. Box 757000, University of Alaska Fairbanks, Fairbanks, AK 99775-7000, USA.



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