A. M. Gerber and M. L. Vallano Pages 805 - 815 ( 11 )
NMDA receptors are linked to neuronal loss in stroke and neurodegeneration because their activation can triggerexcitotoxic Ca2+ dysregulation. Accordingly, NMDA receptor antagonists are neuroprotective, providing a rationale fortheir clinical application. However, side effects often outweigh benefits. Herein we highlight structural properties inreceptors that are used in drug development.
Glutamate, excitotoxicity, NMDA receptor, therapeutics, neurodegeneration, drug design
Department of Neuroscience&Physiology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA.