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Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies

[ Vol. 6 , Issue. 7 ]

Author(s):

A. M. Gerber and M. L. Vallano   Pages 805 - 815 ( 11 )

Abstract:


NMDA receptors are linked to neuronal loss in stroke and neurodegeneration because their activation can triggerexcitotoxic Ca2+ dysregulation. Accordingly, NMDA receptor antagonists are neuroprotective, providing a rationale fortheir clinical application. However, side effects often outweigh benefits. Herein we highlight structural properties inreceptors that are used in drug development.

Keywords:

Glutamate, excitotoxicity, NMDA receptor, therapeutics, neurodegeneration, drug design

Affiliation:

Department of Neuroscience&Physiology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA.



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