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HIV-1 RNase H: Recent Progress in an Exciting, yet Little Explored, Drug Target

[ Vol. 6 , Issue. 6 ]

Author(s):

Enzo Tramontano   Pages 727 - 737 ( 11 )

Abstract:


HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.

Keywords:

HIV-1, Reverse transcriptase, Ribonuclease H, Inhibition, Drug development, N-hydroxyimides, Diketo acids

Affiliation:

Department of Sciences andBiomedical Technologies, University of Cagliari, Cittadella di Monserrato,09142 Monserrato (Cagliari), Italy.



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