Enzo Tramontano Pages 727 - 737 ( 11 )
HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.
HIV-1, Reverse transcriptase, Ribonuclease H, Inhibition, Drug development, N-hydroxyimides, Diketo acids
Department of Sciences andBiomedical Technologies, University of Cagliari, Cittadella di Monserrato,09142 Monserrato (Cagliari), Italy.