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Antibiotics which Target the Wolbachia Endosymbionts of Filarial Parasites: A New Strategy for Control of Filariasis and Amelioration of Pathology

[ Vol. 6 , Issue. 2 ]

Author(s):

K. M. Pfarr and A. M. Hoerauf   Pages 203 - 210 ( 8 )

Abstract:


Wolbachia endosymbionts of filariae are targets for the development of new antifilarial chemotherapy. Doxycycline to deplete Wolbachia from the worm has demonstrated the feasibility of this strategy and has provided a new chemotherapeutic tool. Recent research shows that depleting Wolbachia will also lessen pathology, and lessen adverse reactions to traditional antifilarial drugs.

Keywords:

Lymphatic filariasis, onchocerciasis, Wolbachia, tetracycline, doxycycline

Affiliation:

Institute for MedicalMicrobiology, Immunology and Parasitology, University Clinic Bonn,Sigmund-Freud-Str. 25, D-53105 Bonn, Germany.



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