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Interference with Redox-Active Enzymes as a Basis for the Design of Antimalarial Drugs

[ Vol. 6 , Issue. 2 ]

Author(s):

S. Rahlfs and K. Becker   Pages 163 - 176 ( 14 )

Abstract:


Antimalarial drugs are urgently and continuously required. Parasite enzymes involved in antioxidant defence represent interesting target molecules for rational drug development. Here we summarize the currently available data on structural, biochemical, and functional properties of these proteins in an attempt to evaluate and compare their potential as drug targets.

Keywords:

Plasmodium, drug development, redox metabolism, thioredoxin, glutathione, structure, target validation, malaria

Affiliation:

Interdisciplinary ResearchCenter, Heinrich-Buff-Ring 26-32, Justus-Liebig-University, D-35392Giessen, Germany.



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