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Recent Advances in the Solid-Phase Combinatorial Synthetic Strategies for the Quinoxaline, Quinazoline and Benzimidazole Based Privileged Structures

[ Vol. 6 , Issue. 1 ]


Ahmed Kamal, K. L. Reddy, V. Devaiah, N. Shankaraiah and M. V. Rao   Pages 71 - 89 ( 19 )


Quinoxaline, quinazoline and benzimidazole based templates have been synthesized on solid-support employing different methodologies. This review enlightens academic and industrial examples of combinatorial synthesis for this type of heterocycles that appeared in the literature in the last decade. Hence, some of the important synthetic strategies for the generation of quinoxaline, quinazoline and benzimidazole based privileged structures, and the important biological activities for these heterocycles have been highlighted. Further, benzothiadiazinone, thioxoquinazolinone, cinnoline and indazole are also examined in this review.


benzodiazepine receptor, solid support, Quinazoline derivatives, cell adhesion receptor, cyclocondensation, fibrinogen receptor antagonists, Rink-amide resin


Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India.

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