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Solid-Phase Synthesis of Biologically Interesting Compounds Containing Hydroxamic Acid Moiety

[ Vol. 6 , Issue. 1 ]

Author(s):

Viktor Krchnak   Pages 27 - 36 ( 10 )

Abstract:


Chemical strategies developed for the solid-phase synthesis of hydroxamates are divided into four groups: (i) the traditional synthesis of hydroxamates via cleavage of resin-bound esters by hydroxylamine and its derivatives, (ii) introduction of hydroxamic acid moiety on the resin-bound precursor, (iii) transformation of polymer-supported hydroxylamine, attached to a solid supported linker either by oxygen (O-linking strategy) or by nitrogen (N-linking strategy), and (iv) synthesis of N-alkyl hydroxamates. The scope and limitation of individual approaches are discussed.

Keywords:

Hydroxamic acid, hydroxamate, solid-phase synthesis

Affiliation:

Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, IN 46556, USA.



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