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Solid-Phase Chemistry in the Total Synthesis of Non-Peptidic Natural Products

[ Vol. 6 , Issue. 1 ]

Author(s):

Alvarez Cironi, Mercedes Alvarez and Fernando Albericio   Pages 11 - 25 ( 15 )

Abstract:


Solid-phase chemistry, first introduced for peptide synthesis in the 1960s, has become an integral part of organic synthetic methodology. Presented herein is an overview of recent examples of the use of solid-phase in the preparation of non-peptidic natural products and related compounds, encompassing on-resin total syntheses as well as the use of polymer-supported reagents in solution.

Keywords:

Pictet-Spengler reaction, dehydrative cyclization, antitumor, prostaglandin, Combinatorial libraries, galanthamine-like compounds, carpanone

Affiliation:

Pablo Cironi: Department of Systems Biology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute 44 Binney St, Boston, MA 02115, USA.



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