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Solid-Phase Synthesis in the Twenty-First Century

[ Vol. 6 , Issue. 1 ]

Author(s):

A. Ganesan   Pages 3 - 10 ( 8 )

Abstract:


Solid-phase synthesis is a powerful tool for achieving high-throughput chemistry. This review discusses recent diverse examples from my group: the solid-phase synthesis of unsymmetrical guanidines, polymer-supported versions of cyclooctadiene and 9-BBN, a triflate-like linker, the synthesis of tetrahydro-β-carbolines by the acyliminium Pictet-Spengler reaction, and a total synthesis of the antimycobacterial cyclic depsipeptide natural product kahalalide A.

Keywords:

Solid-phase synthesis, combinatorial chemistry, guanidines, polymer-supported reagents, traceless cleavage, alkaloids, Pictet-Spengler reaction, depsipeptides

Affiliation:

School of Chemistry, University of Southampton, Southampton SO17 1BJ, UK;



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