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Therapeutic Potential of Resveratrol in the Treatment of Glioma: Insights into its Regulatory Mechanisms

[ Vol. 21 , Issue. 18 ]


Ehsan Dadgostar, Maryam Fallah, Fatemeh Izadfar, Reza Heidari-Soureshjani, Michael Aschner, Omid Reza Tamtaji* and Hamed Mirzaei*   Pages 2833 - 2845 ( 13 )


Glioma is a prevalent primary tumor of the brain and spinal cord. Several biological pathways play an important role in the pathogenesis of glioma, including apoptosis, autophagy, cell cycle arrest, migration, and invasion. The low efficacy of chemotherapy and radiation therapy has forced researchers to evaluate alternative treatments for glioma. In this regard, flavonoids have been studied. Resveratrol is a flavonoid with distinct pharmacological activities that has been used in the treatment of various diseases. Several recent studies have also focused on its therapeutic efficacy against glioma. Resveratrol exerts its pharmacological attributes by regulating various molecular and cellular pathways. Here, we review contemporary knowledge in support of the use of resveratrol in the treatment of glioma and its effects on various molecular and cellular mechanisms.


Resveratrol, glioma, apoptosis, autophagy, metastasis.


Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Student Research Committee, Kashan University of Medical Sciences, Kashan, Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Scientific Research Center, Tehran University of medical sciences, Tehran, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, Students' Scientific Research Center, Tehran University of medical sciences, Tehran, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan

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