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Applications of ROS-InducedZr-MOFs Platform in Multimodal Synergistic Therapy

[ Vol. 21 , Issue. 13 ]

Author(s):

Qiongjie Ding, Yiwei Liu, Chuncheng Shi*, Jifei Xiao, Wei Dai, Dong Liu, Haoyuan Chen, Baohong Li* and Jianqiang Liu*   Pages 1718 - 1733 ( 16 )

Abstract:


Background: Metal-organic frameworks (MOFs) possess adjustable aperture, high load capacities, tailorable structures, and excellent biocompatibilities for their use as drug delivery carries in cancer therapy. Until now, Zr-MOFs, in particular, combine optimal stability towards hydrolysis and post synthetic modification with low toxicity, and are widely studied for their excellentbiological performance.

Introduction: This review comprises the exploration of Zr-MOFs as drug delivery devices (DDSs) with a focus on various new methods, including chemotherapy (CT), photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), radiotherapy, immunotherapy, gene therapy and related combined therapies, which all generate reactive oxygen species (ROS) to achieve high efficiency of tumor therapy.

Conclusion: We described and summarized these pertinent examples of the therapeutic mechanisms and highlighted the antitumor effects of their biological application both in vitro and in vivo. The perspectives on their future applications and the analogous challenge of the Zr-MOFs materials are given.

Keywords:

Zr-MOFs, photodynamic therapy, drug delivery, ROS, synergistic therapy.

Affiliation:

Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, Department of Pharmacy, School of Medicine, Xi'an International University, Xi'an, 710077, Shaanxi, International Department, The Affiliated High School of South China Normal University, No.1 Zhongshan Ave. West, Tianhe District, Guangzhou, Guangdong, Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, Shenzhen Huachuang Biopharmaceutical Technology Co. Ltd., Shenzhen, 518112, Guangdong, Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong



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