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A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review

[ Vol. 21 , Issue. 13 ]

Author(s):

Ravinder Sharma, Pooja A. Chawla*, Viney Chawla, Rajeev Verma, Nandita Nawal and Vikas Gupta   Pages 1770 - 1796 ( 27 )

Abstract:


A sizeable proportion of currently marketed drugs come from heterocycles. The heterocyclic moiety 5-pyrazolone is well known five-membered ring containing nitrogen. Derivatives of this wonder nucleus have exhibited activities as diverse as antimicrobial, anti-inflammatory, analgesic, antidepressant, anticonvulsant, antidiabetic, antihyperlipidemic, antiviral, antitubercular, antioxidant, anticancer and antiviral, including action against severe acute respiratory syndrome (SARS) or 3C protease inhibitor. A number of drugs based on this motif have already made it to the market. Standard texts and literature on medicinal chemistry cite different approaches for the synthesis of 5- pyrazolones. The present review provides an insight view to 5-pyrazolone synthesis, their biological profile and structure-activity relationship studies.

Keywords:

Pyrazolones, anti-inflammatory, anticancer, antidepressant, antidiabetic, coronavirus, structure activity relationship.

Affiliation:

Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Faridkot, Punjab, Department of Pharmaceutical Chemistry and Analysis, ISF College of Pharmacy, GT Road, Moga, Punjab, Department of Pharmaceutics, University Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Faridkot, Punjab, Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Sector 1, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow, U.P., Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Sector 1, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow, U.P., University Centre of Excellence in Research, Baba Farid University of Health Sciences, Faridkot, Punjab



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