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Recent Progress in the Drug Development for the Treatment of Alzheimer’s Disease Especially on Inhibition of Amyloid-peptide Aggregation

Author(s):

Yuanyuan Liu, Lin Cong, Chu Han, Bo Li* and Rongji Dai   Pages 1 - 22 ( 22 )

Abstract:


As the world's population is ageing, Alzheimer’s disease (AD) has become a big concern since patients suffering from AD have become younger and the population of AD patients is increasing worldwide. It has been revealed that the neuropathological hallmarks of AD are typically characterized by the presence of neurotoxic extracellular amyloid plaques in the brain, which are surrounded by tangles of neuronal neuronal fibers. However, the causes of AD have not been completely understood yet. Currently, there is no drug to effectively prevent AD or to completely reserve the symptoms in the patients. This article reviews the pathological features associated with AD, the recent research progress on the drug development to treat AD especially on discovery of natural product derivatives to inhibit Aβ peptide aggregation as well as design and synthesis of Aβ peptide aggregation inhibitors to treat AD.

Recent, Progress, in, the, Drug, Development, for, the, Treatment, of, Alzheimer’s, Disease, Especially, on, Inhibition, of, Amyloid-peptide, Aggregation

Affiliation:

Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing, 100081, Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing, 10081, Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing, 100081, Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing, 100081, Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing, 10081



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