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Current and Advanced Nanomaterials in Dentistry as Regeneration Agents: An Update

Author(s):

Mohsen Yazdanian, Aghil Rahmani, Elahe Tahmasebi, Hamid Tebyanian*, Alireza Yazdanian and Seyed Ali Mosaddad   Pages 1 - 20 ( 20 )

Abstract:


In modern dentistry, nanomaterials have strengthened their foothold among tissue engineering strategies for treating bone and dental defects due to a variety of reasons, including trauma and tumors. Besides their finest physiochemical features, the biomimetic characteristics of nanomaterials promote cell growth and stimulate tissue regeneration. The single units of these chemical substances are small-sized particles, usually between 1 to 100 nm, in an unbound state. This unbound state allows particles to constitute aggregates with one or more external dimensions and provide a high surface area. Nanomaterials have brought advances in regenerative dentistry from the laboratory to clinical practice. They are particularly used for creating novel biomimetic nanostructures for cell regeneration, targeted treatment, diagnostics, imaging, and the production of dental materials. In regenerative dentistry, nanostructured matrices and scaffolds help control cell differentiation better. Nanomaterials recapitulate the natural dental architecture and structure and form functional tissues better compared to the conventional autologous and allogenic tissues or alloplastic materials. The reason is that novel nanostructures provide an improved platform for supporting and regulating cell proliferation, differentiation, and migration. In restorative dentistry, nanomaterials are widely used in constructing nanocomposite resins, bonding agents, endodontic sealants, coating materials, and bioceramics. They are also used for making daily dental hygiene products such as mouth rinses. The present article classifies nanostructures and nanocarriers in addition to reviewing their design and applications for bone and dental regeneration.

Keywords:

Nanomaterial, Nanoparticle, Regenerative dentistry, Dental regeneration, Bone regeneration, Nanocomposite resins.

Affiliation:

Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Department of veterinary, Science and Research Branch, Islamic Azad University, Tehran, Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz



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