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Recent Applications of Azo Dyes: A Paradigm Shift from Medicinal Chemistry to Biomedical Sciences

Author(s):

Md. Nasim Khan*, Digvijaysinh K. Parmar and Debasis Das   Pages 1 - 19 ( 19 )

Abstract:


Azo molecules are one of the fascinating organic molecular architectures with azo bond (-N=N-). Since the last century, the bright colored azo molecules are used as dyes for printing, food, paper, cosmetic laser, electronics, optics, material sciences etc. After the discovery of Prontosil as an antibacterial drug, azo molecules became into limelight in medicinal chemistry. Later a number of azo molecules such as Phenazopyridine, Basalazide, Sulfasalazine etc., occupied the drug market. Many azo molecules have been demonstrated as antibacterial, anti-malarial, antifungal, antioxidant, antiviral agents and many more. Metabolic degradation of many azo dyes can cause problem to liver that limits the application of azo dyes in medicinal chemistry. Azo dyes are significantly used in cancer chemotherapy. Recently, a paradigm shift has been observed in the application of azo dyes from medicinal chemistry to biomedical science area. The application of azo molecules in biomedical science such as imaging, drug deliver, photo pharmacology and photo switch areas are reported. In this article, we have complied and discussed the recent work done on azo dye molecules for medicinal importance and future prospects.

Keywords:

Azo compounds, antibacterial, antioxidant, antiviral, bioimaging, biomedical science.

Affiliation:

School of Science, Cardiff University,, Department of Chemistry, Education Hub, Kevdi, Diu college, DHES, Diu (U.T.) - 362520,, Department of Chemistry, RK University, Rajkot, Gujrat-360020



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