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Marine Alkaloid Pityriacitrin and Its Analogues: Discovery, Structures, Synthetic Methods and Biological Properties

[ Vol. 21 , Issue. 2 ]

Author(s):

Shaoyong Ke*, Tingting Xu, Yong Min, Zhongyi Wan, Ziwen Yang and Kaimei Wang*   Pages 233 - 244 ( 12 )

Abstract:


Pityriacitrin is a natural marine alkaloid with a typical β-carboline scaffold, and which has been demonstrated to exhibit diverse biological functions. The special structural features for pityriacitrin lead to the increasing research interest and the emergence of versatile derivatives, and many pityriacitrin analogues have been isolated or synthesized over the past decades. The structural diversity and evolved biological activity of these natural alkaloids can offer opportunities for the development of highly potential novel drugs with a new mechanism of action, and therefore, the aim of this brief review is to describe the discovery, synthesis, and biological properties of natural pityriacitrin and its derivatives, as well as the isolation source.

Keywords:

Marine alkaloid, pityriacitrin, analogues, structure, synthesis, biological properties.

Affiliation:

National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, ubei Academy of Agricultural Sciences, Wuhan 430064, National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, ubei Academy of Agricultural Sciences, Wuhan 430064, National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, ubei Academy of Agricultural Sciences, Wuhan 430064, National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, ubei Academy of Agricultural Sciences, Wuhan 430064, National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, ubei Academy of Agricultural Sciences, Wuhan 430064, National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, ubei Academy of Agricultural Sciences, Wuhan 430064



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