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Drug Re-purposing Approach and Potential Therapeutic Strategies to Treat COVID-19

Author(s):

Eeda Koti Reddy, Srisravanthi Battula, Shaik Anwar* and Ayyiliath M Sajith   Pages 1 - 19 ( 19 )

Abstract:


The current pandemic of Covid-19 caused by SARS-Cov-2 has posed a severe threat to the whole world with its highly infectious, progressive nature and up to 10% mortality rates. The severity of the situation faced by the whole world and lack of efficient therapeutics to treat this viral disease has led the WHO to depend on the drug-repurposing approach to tackle this major global health problem. This review aims at highlighting the various synthetic approaches employed for the synthesis of these FDA approved drugs that have been presently used for Covid-19 treatment. Additionally, a brief overview of several therapeutic strategies is also presented. This review will encourage the scientific community across the globe to come up with better and efficient synthetic protocols and also novel chemical entities along with this core with more potent activity.

Keywords:

Drug Re-purposing, Hydroxychloroquine, COVID-19, SARS-Cov-2, Remdesivir, FDA.

Affiliation:

Vignan's Foundation for Science, Technology and Research-VFSTR (Deemed to be University), Vadlamudi, Guntur 522 213, Andhra Pradesh, Bapatla engineering college, Bapatla, Andhra Pradesh, Vignan's Foundation for Science, Technology and Research-VFSTR (Deemed to be University), Vadlamudi, Guntur 522 213, Andhra Pradesh, Ortin laboratories Pvt. Ltd, Malkapur Village, Choutuppal Mandal, Hyderabad, Telangana



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