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1,8-Naphthyridine Derivatives: A Privileged Scaffold for Versatile Biological Activities

[ Vol. 21 , Issue. 5 ]

Author(s):

Madhwi Ojha, Divya Yadav, Avinash Kumar, Suman Dasgupta and Rakesh Yadav*   Pages 576 - 591 ( 16 )

Abstract:


1, 8- Naphthyridine nucleus belongs to significant nitrogen-containing heterocyclic compounds which has garnered the interest of researchers due to its versatile biological activities. It is known to be used as an antimicrobial, anti-psychotic, anti-depressant, anti-convulsant, anti- Alzheimer’s, anti-cancer, analgesic, anti-inflammatory, antioxidant, anti-viral, anti-hypertensive, antimalarial, pesticides, anti-platelets, and CB2 receptor agonist, etc. The present review highlights the framework of biological properties of synthesized 1, 8-naphthyridine derivatives developed by various research groups across the globe.

Keywords:

1, 8-Naphthyridine derivatives, nalidixic acid, gemifloxacin, enoxacin, voreloxin, tosufolxacin.

Affiliation:

Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan-304022, Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan-304022, Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka- 576104, Department of Molecular Biology & Biotechnology, Tezpur University, Nappam, Sonitpur-784028, Assam, Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan-304022



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