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Modulation of Calcium Signaling in Glioblastoma Multiforme: A Therapeutic Promise for Natural Products

Author(s):

Amir R. Afshari, Hamid Mollazadeh, Mohammad Soukhtanloo, Azar Hosseini, Elmira Mohtashami, Mohammad Jalili-Nik, Seyed Mohamad Sadegh Modaresi, Arash Soltani and Amirhossein Sahebkar*   Pages 1 - 21 ( 21 )

Abstract:


Glioblastoma multiforme (GBM) continues as one of the most lethal cerebral cancers despite standard therapeutic modalities, such as maximum surgical resection and chemoradiation. The minimal effectiveness of existing therapies necessitates the development of additional drug candidates that could improve the prognosis of GBM patients. Accumulating evidence suggests that calcium (Ca2+) is involved in the processes of cell proliferation, metastasis, angiogenesis, migration, and invasiveness. Therefore, Ca2+ could serve as a crucial regulator of tumorigenesis and a potential treatment target in GBM. In this context, specific natural products are known to modulate Ca2+ signaling pathways implicated in tumor growth, apoptosis, angiogenesis, and development of GBM. Here, we focus on the function of Ca2+ as a therapeutic target in GBM and review certain natural products that affect the signaling pathways of Ca2+.

Keywords:

Glioblastoma multiforme, Calcium, Metastasis, Natural products, apoptosis, angiogenesis.

Affiliation:

Department of Physiology and Pharmacology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, College of Pharmacy, University of Rhode Island, Kingston, Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad



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