Mahvish Abbasi, Munazzah Yaqoob, Rosenani A. Haque and Muhammad Adnan Iqbal* Pages 69 - 78 ( 10 )
Development of novel metallodrugs with pharmacological profile plays a significant role in modern medicinal chemistry and drug design. Metal complexes have shown remarkable clinical results in current cancer therapy. Gold complexes have attained attention due to their high antiproliferative potential. Gold-based drugs are used for the treatment of rheumatoid arthritis. Gold-containing compounds with selective and specific targets are capable to assuage the symptoms of a range of human diseases. Gold (I) species with labile ligands (such as Cl in TEPAuCl) interact with isolated DNA; therefore, this biomolecule has been considered as a target for gold drugs. Gold (I) has a high affinity towards sulfur and selenium. Due to this, gold (I) drugs readily interact with cysteine or selenocysteine residue of the enzyme to form protein-gold(I) thiolate or protein-gold (I) selenolate complexes that lead to inhibition of the enzyme activity. Au(III) compounds due to their square-planner geometriesthe same as found in cisplatin, represent a good source for the development of anti-tumor agents. This article aims to review the most important applications of gold products in the treatment of human colon cancer and to analyze the complex interplay between gold and the human body.
Medicinal application of gold, phosphane complexes, auranofin, NHCs, colon cancer, cancer therapy.
Department of Chemistry, University of Agriculture Faisalabad-38040, Department of Chemistry, University of Agriculture Faisalabad-38040, School of Chemical Sciences, Universiti Sains Malaysia, 11800-USM, Penang, Department of Chemistry, University of Agriculture Faisalabad-38040