Shubham Khot, Pratibha B. Auti* and Samrat A. Khedkar Pages 135 - 149 ( 15 )
The current review discusses the different synthetic pathways for one of the most important and interesting heterocyclic ring systems, 1,4-dihydropyridine. This cyclic system depicts diverse pharmacological action on several receptors, channels, and enzymes. Dihydropyridine moiety plays an important role in several calcium-channel blockers. Moreover, it has been exploited for the treatment of a variety of cardiovascular diseases due to its potential antihypertensive, anti-angina, vasodilator, and cardiac depressant activities. Furthermore, it also shows antibacterial, anticancer, anti-leishmanial, anticoagulant, anticonvulsant, anti-tubercular, antioxidant, antiulcer, and neuroprotective properties. Several reports have demonstrated dihydropyridine derivatives as a potentiator of cystic fibrosis transmembrane conductance regulator protein, potent antimalarial agent and HIV-1 protease inhibitor. Herein, we have briefly reviewed different novel chemistry and the synthesis of 1,4-dihydropyridine.
Dihydropyridine, anticancer, anti-tubercular, ionizing radiation, anti-leishmanial, HIV-1.
Department of Pharmaceutical Chemistry, STES’s Sinhgad Institute of Pharmacy, Narhe, Pune-41, Maharashtra, Department of Pharmaceutical Chemistry, STES’s Sinhgad Institute of Pharmacy, Narhe, Pune-41, Maharashtra, Shikshan Prasarak Mandal’s College of Pharmacy, Akluj (Degree) Tal, Malshiras, Dist. Solapur 413101, Maharashtra