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Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules

[ Vol. 21 , Issue. 2 ]

Author(s):

Shubham Khot, Pratibha B. Auti* and Samrat A. Khedkar   Pages 135 - 149 ( 15 )

Abstract:


The current review discusses the different synthetic pathways for one of the most important and interesting heterocyclic ring systems, 1,4-dihydropyridine. This cyclic system depicts diverse pharmacological action on several receptors, channels, and enzymes. Dihydropyridine moiety plays an important role in several calcium-channel blockers. Moreover, it has been exploited for the treatment of a variety of cardiovascular diseases due to its potential antihypertensive, anti-angina, vasodilator, and cardiac depressant activities. Furthermore, it also shows antibacterial, anticancer, anti-leishmanial, anticoagulant, anticonvulsant, anti-tubercular, antioxidant, antiulcer, and neuroprotective properties. Several reports have demonstrated dihydropyridine derivatives as a potentiator of cystic fibrosis transmembrane conductance regulator protein, potent antimalarial agent and HIV-1 protease inhibitor. Herein, we have briefly reviewed different novel chemistry and the synthesis of 1,4-dihydropyridine.

Keywords:

Dihydropyridine, anticancer, anti-tubercular, ionizing radiation, anti-leishmanial, HIV-1.

Affiliation:

Department of Pharmaceutical Chemistry, STES’s Sinhgad Institute of Pharmacy, Narhe, Pune-41, Maharashtra, Department of Pharmaceutical Chemistry, STES’s Sinhgad Institute of Pharmacy, Narhe, Pune-41, Maharashtra, Shikshan Prasarak Mandal’s College of Pharmacy, Akluj (Degree) Tal, Malshiras, Dist. Solapur 413101, Maharashtra



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