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Review on Dengue Virus Fusion/Entry Process and Their Inhibition by Small Bioactive Molecules

Author(s):

Podila Naresh, Shyam Sunder Pottabatula and Jubie Selvaraj *   Pages 1 - 15 ( 15 )

Abstract:


Many flavi viruses are noteworthy human pathogens which might be spread by means of mosquitoes and ticks. Despite the availability of vaccines for virus infections such as yellow fever virus, Japanese encephalitic virus, and tickborne encephalitis virus, still flavi virus like dengue is a serious life threatening disease globally. So far, there is no antiviral drug for dengue therapy. In order to address this scientific want, industry and scholarly community have been taking continuos measures to increase the anti flavivirus therapy. In the last two decades, active research is involved in inhibiting the fusion process of the virus entry. In this review, we have comprehensively given the present day expertise of usage of small molecules utilized as fusion inhibitors. We have enumerated the structure, fusion process of dengue virus E protein (DENV E) and amino acids involved during the fusion process. Special emphasis have been given for the small molecules that do conformational changes of DENV E protein viz. blocking the βOG pocket which is vital for fusion.

Keywords:

Dengue, Flavivirus, Envelop protein, Hinge, βOG, Fusion.

Affiliation:

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Udhagamandalam, JSS Academy of Higher Education & Research, Mysore, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Udhagamandalam, JSS Academy of Higher Education & Research, Mysore, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Udhagamandalam, JSS Academy of Higher Education & Research, Mysore



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