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The Quinazoline-Chalcone and Quinazolinone-Chalcone Hybrids: A Promising Combination for Biological Activity

Author(s):

Eduardo Bustos Mass*, Gilmar Vieira Duarte and Dennis Russowsky   Pages 1 - 18 ( 18 )

Abstract:


Quinazoline and/or chalcones derivatives are important targets in several areas of chemical sciences, mainly, in the medicinal chemistry and pharmaceutical research. The purpose of this review is to systematize the information available in the literature, including patents, regarding the benefits exerted by the combination of these two pharmacophores into single molecules. These hybrid compounds can exhibit different biological activities, causing a synergistic or a new effect, compared to the individuals. The variability of biological activities includes anticancer, anti-Alzheimer, antiviral and antimicrobial activities, among others. Additionally, synthetic methodologies to prepare the different molecular architectures were discussed based on their similarities. The increasing number of publications indicates the importance of molecular hybridization on the field of drug discovery.

Keywords:

Quinazoline, Quinazolinone, Chalcone, Hybrids, Biological Activity, Anticancer, Antimicrobial, Anti-inflammatory.

Affiliation:

Laboratório de Sínteses Orgânicas, Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, CEP 91501-970, Agronomia, Porto Alegre, RS, Laboratório de Sínteses Orgânicas, Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, CEP 91501-970, Agronomia, Porto Alegre, RS, Laboratório de Sínteses Orgânicas, Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, CEP 91501-970, Agronomia, Porto Alegre, RS



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